Important Safety Information

TWINRIX® is a combined hepatitis A (inactivated) and hepatitis B (recombinant) vaccine to be used in adults, adolescents, children and infants over one year of age.

TWINRIX® does not protect against hepatitis C or E nor does it treat hepatitis A or B infections.
100% protection cannot be guaranteed and booster doses may be required.

Side effects that occurred in adults during clinical trials with the standard (3 dose) and the rapid (4 dose) TWINRIX® vaccination schedule were as follows:

  • Adult: Very common (more than 10% of doses) – pain or discomfort, redness at the injection site, headache and tiredness.
  • Adult: Common (1-10% of doses) – swelling at the injection site, diarrhea, nausea, vomiting and generally feeling unwell.
  • Adult: Uncommon (0.1-1% of doses) – fever (over 37.5°C), dizziness, upper respiratory tract infection, and aching muscles.
  • Adult: Rare (0.01-0.1% of doses) – swollen glands in the neck, armpit or groin, loss of appetite, pins and needles, low blood pressure, rash and itching, muscle and joint pain and flu-like symptoms, such as high temperature, sore throat, runny nose, cough, and chills.
  • Adult: Very rare (less than 0.01% of doses) – hives.

Side effects that occurred in children during clinical trials who received the standard (3 dose) TWINRIX® Jr. vaccination schedule were as follows:

  • Children: Very common (more than 10% of doses) – pain and redness at the injection site.
  • Children: Common (1-10% of doses) – swelling at the injection site, fever over 37.5°C, irritability, drowsiness, headache, loss of appetite, diarrhea, nausea, vomiting and generally feeling unwell.
  • Children: Uncommon (0.1-1% of doses) – rash.
  • Children: Rare (0.01-0.1% of doses) – swollen glands in the neck, armpit or groin, dizziness and hives.
  • Children: Very rare (less than 0.01% of doses) – pins and needles, loss of skin sensitivity to pain or touch, numbness of the arms and legs, low blood pressure, rash and itching, aching muscles and joint pain and flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills.

Side effects that occurred in children during clinical trials who received the alternate (2 dose) TWINRIX® vaccination schedule were as follows:

  • Children: Very common (more than 10% of doses) – pain and redness at the injection site, tiredness, headache, irritability and loss of appetite.
  • Children: Common (1-10% of doses) – swelling at the injection site, fever, drowsiness, stomach and digestive complaints.

Ask your healthcare provider if TWINRIX® is right for you.