About TWINRIX®

  • The TWINRIX® vaccine works by helping your body produce its own protection (antibodies) against hepatitis A and B.
  • TWINRIX® may be used in adults, adolescents, children and infants over one year of age.
  • TWINRIX® is administered as an intramuscular injection by a healthcare professional.
  • Side effects that occurred in adults during clinical trials with the standard (3 dose) and the rapid (4 dose) TWINRIX® vaccination schedule were as follows:
    • Adult: Very common (more than 10% of doses) – pain or discomfort, redness at the injection site, headache and tiredness.
    • Adult: Common (1-10% of doses) – swelling at the injection site, diarrhea, nausea, vomiting and generally feeling unwell.
    • Adult: Uncommon (0.1-1% of doses) – fever (over 37.5°C), dizziness, upper respiratory tract infection, and aching muscles.
    • Adult: Rare (0.01-0.1% of doses) – swollen glands in the neck, armpit or groin, loss of appetite, pins and needles, low blood pressure, rash and itching, muscle and joint pain and flu-like symptoms, such as high temperature, sore throat, runny nose, cough, and chills.
    • Adult: Very rare (less than 0.01% of doses) – hives.
  • Side effects that occurred in children during clinical trials who received the standard (3 dose) TWINRIX® Jr. vaccination schedule were as follows:
    • Children: Very common (more than 10% of doses) – pain and redness at the injection site.
    • Children: Common (1-10% of doses) – swelling at the injection site, fever over 37.5ºC, irritability, drowsiness, headache, loss of appetite, diarrhea, nausea, vomiting and generally feeling unwell.
    • Children: Uncommon (0.1-1% of doses) – rash.
    • Children: Rare (0.01-0.1% of doses) – swollen glands in the neck, armpit or groin, dizziness and hives.
    • Children: Very rare (less than 0.01% of doses) – pins and needles, loss of skin sensitivity to pain or touch, numbness of the arms and legs, low blood pressure, rash and itching, aching muscles and joint pain and flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills.
  • Side effects that occurred in children during clinical trials who received the alternate (2 dose) TWINRIX® vaccination schedule were as follows:
    • Children: Very common (more than 10% of doses) – pain and redness at the injection site, tiredness, headache, irritability and loss of appetite.
    • Children: Common (1-10% of doses) – swelling at the injection site, fever, drowsiness, stomach and digestive complaints.
  • Do not be alarmed by this list of possible side effects. It is likely that you will have no side effects from vaccination.
    This is not a complete list of side effects. For any unexpected effects while taking TWINRIX®, contact your doctor or pharmacist.

  • People who have a fever or anything more serious than a minor cold should postpone vaccination. Pregnant women should discuss the possible risks and benefits of vaccination with their doctor.

Timing of TWINRIX® vaccine doses:

Example in adults, adolescents, children and infants over one year of age

The standard TWINRIX® schedule consists of 3 vaccine doses:

  1. You choose the date.
  2. One month after the first dose.
  3. Six months after the first dose.
Vaccination Dosing Schedules

Immunization may not be suitable for everyone and can be associated with adverse effects. Be sure to consult your healthcare provider to see which options are right for you. 100% protection cannot be guaranteed and booster doses may be required.

Talk to your healthcare
provider about TWINRIX®